See how a next-generation low-volume, ready-to-drink bowel prep
can help support a successful colon cleanse for your patients1

Learn More

See how a next-generation low-volume,
ready-to-drink bowel prep can help support a
successful colon cleanse for your patients1

See New Data

Split-dose CLENPIQ demonstrated proven efficacy in cleansing the entire colon1,2*

88% of patients achieved successful cleansing of the overall colon1,2*

The primary endpoint was the proportion of patients with successful colon cleansing, defined as “excellent” or “good”

Scoring was performed before washing and suctioning

*Trial Design: The safety and efficacy of CLENPIQ were evaluated in a randomized, multicenter, controlled, assessor-blinded trial. CLENPIQ® (sodium picosulfate, magnesium oxide, and anhydrous citric acid) Oral Solution (SPMC) was administered in a split-dose regimen against an oral powder (for reconstitution) (P/MC powder) and efficacy was evaluated using 2 different measurement scales.2 In this trial, CLENPIQ patients were instructed to drink at least five 8-ounce glasses of clear liquid within 5 hours of the first dose of CLENPIQ and at least four 8-ounce glasses of clear liquid within 4 hours of the second dose.2

Split-dose CLENPIQ demonstrated proven efficacy in cleansing all segments of the colon2*

94% of patients achieved successful cleansing of the ascending colon2*

Segmental colon

Assessed using the Boston Bowel Preparation scale2

Secondary efficacy endpoints were the proportion of patients with successful cleansing of the ascending, transverse, and descending colon, defined as a segmental score of “3” or “2”2

Scoring was performed after washing and suctioning2

Established safety profile1,2

The most common adverse reactions (≥ 2%) observed in the adult CLENPIQ split-dose clinical trial were nausea (3%), headache (3%), hypermagnesemia (2%), abdominal pain (2%), and dehydration or dizziness (2%).1,2

Hypermagnesemia levels were transient and not associated with any clinical significant sequelae. Eight of the 9 patients with hypermagnesemia returned to baseline within 24 to 48 hours. One patient returned to baseline by the day 7 follow-up visit.1,2

1% of patients taking CLENPIQ experienced vomiting.2

Patient compliance and tolerability were evaluated2†

Results from the Mayo Clinic Bowel Preparation Tolerability Questionnaire:

  • 99% of patients completed the majority of the CLENPIQ prep
  • 98% said they would be mostly or somewhat willing to take CLENPIQ again2
  • 90% felt that the tolerability of CLENPIQ was “easy” or “acceptable”2

Trial Design: The efficacy and safety of CLENPIQ were evaluated in a randomized, multicenter, controlled, assessor-blinded trial. CLENPIQ® (sodium picosulfate, magnesium oxide, and anhydrous citric acid) Oral Solution (SPMC) was administered in a split-dose regimen against an oral powder (for reconstitution) (P/MC powder) and efficacy was evaluated using 2 different measurement scales.2

Subject compliance and tolerability with the bowel preparations were assessed by the validated Mayo Clinic Bowel Prep Tolerability Questionnaire, administered to patients on the day of their colonoscopies prior to the procedure.2

§Majority was defined as <25% of the bowel prep remaining after dosing.

Results from the questionnaire demonstrated that there was a high degree of tolerability and willingness to use CLENPIQ in the future2

Can CLENPIQ help your patients prep for a successful procedure?

CLENPIQ is the next-generation low-volume, ready-to-drink bowel prep1

  • LOWEST VOLUME OF ACTIVE MEDICATION COMPARED WITH SUPREP®, PLENVU®, AND MOVIPREP ®1,4-6*
  • NO MIXING OR DILUTING1
  • SUPPLIED IN TWO 5.4-OZ, READY-TO-DRINK BOTTLES1*

*Additional clear liquids are required for hydration.1,4-6

CLENPIQ provides split-dose Instructions for Use that are easy to follow

Click here to download the full instructions.

To open the CLENPIQ bottle: Place the bottle on a flat surface. Push down on the cap while twisting to the left (counterclockwise). Twist the cap until you see the white plastic ring under the cap is broken.

Drink, hydrate, repeat1

Clenpiq Split-Dose
Night Before
5:00 to 9:00 PM

Drink five or more 8 ounce (oz) cups of clear liquids over the next 5 hours

MORNING OF
5 hours before the procedure

Drink four or more 8 ounce (oz) cups (32 oz) of clear liquids. All clear liquid must be finished at least 2 hours before the procedure

See below for step-by-step instructions.

  • Patient should hydrate on the day before the procedure and consume only clear liquids.1,3

Download easy-to-follow instructions for your patients taking split-dose CLENPIQ.

Step-By-Step Split-Dose Administration

Dose 1 – On the day before the colonoscopy1:

  • Instruct patients to consume only clear liquids (no solid food or dairy) on the day before the colonoscopy up until 2 hours before the time of the colonoscopy
  • Take the first dose (1 bottle) of CLENPIQ during the evening before the colonoscopy (eg, 5:00 to 9:00 pm)
  • Follow CLENPIQ by drinking five or more 8-ounce cups (cup provided) of clear liquids (40 ounces total) within 5 hours and before bed
  • If severe bloating, distention, or abdominal pain occurs following the first dose, delay the second dose until the symptoms resolve

Dose 2 – Next morning on the day of the colonoscopy (start approximately 5 hours prior to colonoscopy)1:

  • Continue to consume only clear liquids (no solid food or dairy)
  • Take the second dose (the second bottle) of CLENPIQ
  • Following the CLENPIQ dose, drink four or more 8-ounce cups (cup provided) of clear liquids (32 ounces) at least 2 hours before the colonoscopy

Hydration is an important part of the prep

Patients can hydrate with any of the following clear liquids:

  • Water (plain or flavored)
  • Black coffee or tea (no milk, cream, soy, or nondairy creamer)
  • Clear broth or bouillon
  • Sports drinks (not red or purple)
  • Clear juices without pulp (such as apple juice or white grape juice)
  • Ginger ale and other sodas (not red or purple)
  • Plain Jell-O® (not red or purple)
  • Frozen juice popsicles (not red or purple)

CLENPIQ savings support

Download the CLENPIQ coupon to help eligible patients save

The coupon can be used for commercially insured and cash-paying patients

Download the CLENPIQ coupon and your patients may be eligible to pay as little as $40 if they have commercial insurance, or to take $40 off the cash price. Terms and conditions apply.

Healthcare providers may download up to 10 cards
at a time.

*Plus applicable sales tax. Subject to eligibility and maximum benefit allowed.

References
  1. CLENPIQ® [Prescribing Information]. Parsippany, NJ: Ferring Pharmaceuticals Inc.
  2. Hookey L, et al. Efficacy and safety of a ready-to-drink bowel preparation for colonoscopy: a randomized, controlled, non-inferiority trial. Therap Adv Gastroenterol. 2019, vol. 12: 1-13.
  3. Lichtenstein GR, Cohen LB, Uribarri J. Review article: bowel preparation for colonoscopy the importance of adequate hydration. Aliment Pharmacol Ther. 2007;26(5):633-641.
  4. SUPREP® Bowel Prep Kit [Prescribing Information]. Braintree, MA: Braintree Laboratories, Inc.
  5. PLENVU® [Prescribing Information]. Bridgewater, NJ: Salix Pharmaceuticals.
  6. MoviPrep® [Prescribing Information]. Bridgewater, NJ: Salix Pharmaceuticals.

Indication

CLENPIQ® oral solution is indicated for cleansing of the colon as a preparation for colonoscopy in adults and pediatric patients ages 9 years and older.

Important Safety Information

  • CLENPIQ is contraindicated in the following conditions: patients with severe reduced renal impairment (creatinine clearance less than 30mL/minute), gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, or in patients with a known hypersensitivity to any of the ingredients in CLENPIQ.
  • Patients should be advised to hydrate adequately (before, during and after use of CLENPIQ), and post-colonoscopy lab tests should be considered if a patient develops significant vomiting or signs of dehydration, including orthostatic hypotension, after taking CLENPIQ. Patients with electrolyte abnormalities should have them corrected before treatment. Use caution when prescribing CLENPIQ for patients that have conditions or are using medications that increase the risk for fluid and electrolyte disturbances.
  • Use caution in patients who have conditions, or are taking concomitant medications that increase the risk for seizures, such as those taking medications that lower the seizure threshold, patients withdrawing from alcohol or benzodiazepines or patients with known or suspected hyponatremia.
  • Use caution in patients with impaired renal function or taking medications that may affect renal function, as well as patients at increased risk of arrhythmias, including those patients with a history of prolonged QT, recent myocardial infarction, unstable angina, congestive heart failure, or cardiomyopathy.
  • Osmotic laxatives may produce colonic mucosal aphthous ulcerations and there have been reports of more serious cases of ischemic colitis requiring hospitalization. Concurrent use of additional stimulant laxatives with CLENPIQ may increase this risk.
  • Use with caution in patients with severe active ulcerative colitis.
  • Patients with impaired gag reflex are at risk for regurgitation or aspiration during administration of CLENPIQ. Observe these patients during administration of CLENPIQ.
  • The most common adverse reactions reported in a clinical trial with CLENPIQ for colon cleansing in adults were nausea, headache, hypermagnesemia, abdominal pain, and dehydration or dizziness. The most common adverse reactions reported in a clinical trial of another sodium picosulfate, magnesium oxide and anhydrous citric acid product for colon cleansing in pediatric patients aged 9 to 16 years were nausea, vomiting and abdominal pain.
  • CLENPIQ can reduce the absorption of co-administered drugs. Do not take oral medications within one hour of starting CLENPIQ. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, at least 2 hours before and not less than 6 hours after administration of CLENPIQ to avoid chelation with magnesium.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch, or call 800.FDA.1088.
Please see accompanying full Prescribing Information.

Reference
1. CLENPIQ® [Prescribing Information]. Parsippany, NJ: Ferring Pharmaceuticals Inc.

Indication

CLENPIQ® oral solution is indicated for cleansing of the colon as a preparation for colonoscopy in adults and pediatric patients ages 9 years and older.

Important Safety Information

  • CLENPIQ is contraindicated in the following conditions: patients with severe reduced renal impairment (creatinine clearance less than 30mL/minute), gastrointestinal obstruction or ileus, bowel perforation, toxic colitis or toxic megacolon, gastric retention, or in patients with a known hypersensitivity to any of the ingredients in CLENPIQ.
  • Patients should be advised to hydrate adequately (before, during and after use of CLENPIQ), and post-colonoscopy lab tests should be considered if a patient develops significant vomiting or signs of dehydration, including orthostatic hypotension, after taking CLENPIQ. Patients with electrolyte abnormalities should have them corrected before treatment. Use caution when prescribing CLENPIQ for patients that have conditions or are using medications that increase the risk for fluid and electrolyte disturbances.
  • Use caution in patients who have conditions, or are taking concomitant medications that increase the risk for seizures, such as those taking medications that lower the seizure threshold, patients withdrawing from alcohol or benzodiazepines or patients with known or suspected hyponatremia.
  • Use caution in patients with impaired renal function or taking medications that may affect renal function, as well as patients at increased risk of arrhythmias, including those patients with a history of prolonged QT, recent myocardial infarction, unstable angina, congestive heart failure, or cardiomyopathy.
  • Osmotic laxatives may produce colonic mucosal aphthous ulcerations and there have been reports of more serious cases of ischemic colitis requiring hospitalization. Concurrent use of additional stimulant laxatives with CLENPIQ may increase this risk.
  • Use with caution in patients with severe active ulcerative colitis.
  • Patients with impaired gag reflex are at risk for regurgitation or aspiration during administration of CLENPIQ. Observe these patients during administration of CLENPIQ.
  • The most common adverse reactions reported in a clinical trial with CLENPIQ for colon cleansing in adults were nausea, headache, hypermagnesemia, abdominal pain, and dehydration or dizziness. The most common adverse reactions reported in a clinical trial of another sodium picosulfate, magnesium oxide and anhydrous citric acid product for colon cleansing in pediatric patients aged 9 to 16 years were nausea, vomiting and abdominal pain.
  • CLENPIQ can reduce the absorption of co-administered drugs. Do not take oral medications within one hour of starting CLENPIQ. Administer tetracycline and fluoroquinolone antibiotics, iron, digoxin, chlorpromazine and penicillamine, at least 2 hours before and not less than 6 hours after administration of CLENPIQ to avoid chelation with magnesium.

You are encouraged to report negative side effects of prescription drugs to FDA. Visit www.FDA.gov/medwatch, or call 800.FDA.1088.
Please see accompanying full Prescribing Information.